2-杂环基-1,3,4-噁二嗪酮类化合物的合成及其除草活性

Synthesis and herbicidal activity of 2-heterocyclic- 1,3,4-oxadiazine-5-ones

摘要: 以取代杂环羧酸为起始原料,在1,3,4-噁二嗪-5-酮的2-位上分别引入呋喃环、吡啶环及氯代噻吩环,合成了31个未见报道的2-杂环基-1,3,4-噁二嗪酮化合物,其化学结构经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,该类化合物具有良好的除草活性,如在质量浓度200 mg/L时,化合物 E14、E16、E20、E21 对马唐Digitaria sanguinalis的抑制率大于90%,化合物 E06、E07、E10、E14、E16、E20 对苋菜Ambrosia tricolor的抑制率也大于90%。

Abstract: Thirty one novel compounds of 2-heterocyclic-1,3,4-oxadiazine-5-one derivatives were synthesized through the starting material substituted heterocyclic carboxylic acid.The structure of all compounds was confirmed by 1H NMR and elemental analysis.The preliminary assays showed that some compounds exhibited significant herbicidal activity.The inhibition rate of E14,E16,E20 and E21 to the Digitaria sanguinalis and E06,E07,E10,E14,E16 and E20 to the Ambrosia tricolor reached 90% at the mass concentration of 200 mg/L.