Abstract:
Twenty-three derivatives of tenvermectin B, tenvermectin B monosaccharide and tenvermectin B aglycone were synthesized by introducing different acyl groups at the C-13, C-4′ and C-4′′ sites after the selective protection of C-5 hydroxyl group. All target compounds were characterized by
1H NMR,
13C NMR and high resolution mass spectra. Their insecticidal activities were tested against
Plutella xylostella,
Tetranychus cinnabarinus and
Bursaphelenchus xylophilus. All the tested compounds showed significant secticidal activities against the above mentioned three insect species and the 4″-tenvermectin B derivatives were superior to the 4′- and 13-derivatives of tenvermectin B. Compound
8e displayed potentactivity to
P. xylostella and
B. xylophilus with LC
50 values of 9.2 mg/L and 0.42 mg/L, respectively. Moreover, compound
8b showed the best inhibitory activity against
T. cinnabarinus with LC
50 value of 0.001 9 mg/L, which was superior to that of tenvermectin B.