徐莉, 王建华, 梅宇, 李冬植. 解毒酶和转运蛋白介导的害虫抗药性分子机制研究进展[J]. 农药学学报, 2020, 22(1): 1-10. DOI: 10.16801/j.issn.1008-7303.2020.0016
    引用本文: 徐莉, 王建华, 梅宇, 李冬植. 解毒酶和转运蛋白介导的害虫抗药性分子机制研究进展[J]. 农药学学报, 2020, 22(1): 1-10. DOI: 10.16801/j.issn.1008-7303.2020.0016
    XU Li, WANG Jianhua, MEI Yu, LI Dongzhi. Research progress on the molecular mechanisms of insecticides resistance mediated by detoxification enzymes and transporters[J]. Chinese Journal of Pesticide Science, 2020, 22(1): 1-10. DOI: 10.16801/j.issn.1008-7303.2020.0016
    Citation: XU Li, WANG Jianhua, MEI Yu, LI Dongzhi. Research progress on the molecular mechanisms of insecticides resistance mediated by detoxification enzymes and transporters[J]. Chinese Journal of Pesticide Science, 2020, 22(1): 1-10. DOI: 10.16801/j.issn.1008-7303.2020.0016

    解毒酶和转运蛋白介导的害虫抗药性分子机制研究进展

    Research progress on the molecular mechanisms of insecticides resistance mediated by detoxification enzymes and transporters

    • 摘要: 害虫抗药性是导致杀虫剂防效降低的一个重要因素,而抗性机制的阐明是害虫抗药性综合治理的基础。研究表明,代谢能力增强是害虫抗药性产生的重要原因,害虫对杀虫剂等外源物质的代谢需要细胞色素P450酶系 (P450s)、羧酸酯酶 (CarEs)、谷胱甘肽S-转移酶 (GSTs)、UDP-葡萄糖醛酸转移酶 (UGTs) 和ATP结合盒转运蛋白 (简称ABC转运蛋白) 等解毒酶和转运蛋白的参与。结合近年来对害虫抗药性分子机制的研究进展,本文综述了上述解毒酶和转运蛋白参与杀虫剂抗药性的分子机制,并对害虫抗药性治理的新方法进行了展望。

       

      Abstract: Insecticides resistance is a key threat to the application of insecticides. The elucidation of molecular mechanisms of insecticides resistance is the basis for the integrated pest management. The increased metabolism of insecticides is an important reason for insecticide resistance. Cytochrome P450 enzyme systems (P450s), carboxylesterases (CarEs), glutathione S-transferases(GSTs), UDP-glycosyltransferases (UGTs) and ATP-binding cassette (ABC) transport proteins are involved in the metabolism of xenobiotics in insects. The molecular mechanisms of those five detoxification enzymes and transporter systems participated in insecticide resistance were summarized according to the research progress in the recent years. Finally, the outlook of new methods for insect control were provided.

       

    /

    返回文章
    返回