韩永涛, 张艳峰, 王会利. 异菌脲在葱上的残留行为及长期膳食风险评估[J]. 农药学学报, 2020, 22(6): 1033-1039. DOI: 10.16801/j.issn.1008-7303.2020.0153
    引用本文: 韩永涛, 张艳峰, 王会利. 异菌脲在葱上的残留行为及长期膳食风险评估[J]. 农药学学报, 2020, 22(6): 1033-1039. DOI: 10.16801/j.issn.1008-7303.2020.0153
    HAN Yongtao, ZHANG Yanfeng, WANG Huili. Residue behavior and long-term dietary risk assessment of iprodione in shallot[J]. Chinese Journal of Pesticide Science, 2020, 22(6): 1033-1039. DOI: 10.16801/j.issn.1008-7303.2020.0153
    Citation: HAN Yongtao, ZHANG Yanfeng, WANG Huili. Residue behavior and long-term dietary risk assessment of iprodione in shallot[J]. Chinese Journal of Pesticide Science, 2020, 22(6): 1033-1039. DOI: 10.16801/j.issn.1008-7303.2020.0153

    异菌脲在葱上的残留行为及长期膳食风险评估

    Residue behavior and long-term dietary risk assessment of iprodione in shallot

    • 摘要: 2018年在山东、安徽、广西、河北、黑龙江和河南6地进行异菌脲在葱上的规范残留试验,建立了气相色谱-质谱 (GC-MS) 测定葱中异菌脲残留的分析方法。样品经乙酸乙酯提取,N-丙基乙二胺 (PSA)、十八烷基键合硅胶 (C18) 和石墨化碳黑 (GCB) 净化,GC-MS检测。结果表明:在0.02~20 mg/L范围内,异菌脲质量浓度与其峰面积呈良好的线性关系,相关系数大于0.99。在0.05、0.5和20 mg/kg添加水平下,异菌脲在葱中的平均回收率为81%~96%,相对标准偏差 (RSD) 为3%~9%,定量限为0.05 mg/kg。异菌脲在葱中的消解符合一级反应动力学方程,半衰期为12.2~15.8 d。采用255 g/L异菌脲悬浮剂按有效成分750和1125 g/hm2施药2~3次,于末次施药后3、5、7和14 d采样测定,葱中异菌脲的残留量为2.53~15.6 mg/kg。采用风险最大化的原则进行长期膳食风险评估,结果表明:一般人群异菌脲的国家估算每日摄入量 (NEDI) 为2.0650 mg,占日允许摄入量的54.6%,异菌脲在葱中的残留不会对一般人群健康造成不可接受的风险。

       

      Abstract: Supervised field trials were conducted in Shandong, Anhui, Guangxi, Hebei, Heilongjiang and Henan province in 2018. A highly efficient and simple method was developed for the determination of iprodione in shallot using gas chromatography-mass spectrometry (GC-MS). The samples were extracted with ethyl acetate, purified with primary secondary amine (PSA), octadecylsilane (C18) and graphitized carbon black (GCB), and detected by GC-MS. A good linear relationship between the peak area and the concentration of iprodione was observed in the range of 0.02-20 mg/L with the correlation coefficient greater than 0.99. The recoveries of iprodione in shallot ranged from 81% to 96% with the RSDs of 3%-9% at the spiked levels of 0.05, 0.5 and 20 mg/kg. The limit of quantitation of iprodione was 0.05 mg/kg. Results showed that the dissipation of iprodione in shallot fitted to the first order kinetics with the half-lives ranged from 12.2 to 15.8 d. The 255 g/L suspension concentrate (SC) of iprodione was sprayed at 750 and 1125 g a.i./hm2 for 2-3 times on shallot. Then samples were taken and determined at 3, 5, 7 and 14 d after the last application. Results indicated that the residue of iprodione in shallot was 2.53-15.6 mg/kg. Finally, the long-term dietary risk assessment was conducted using the principle of risk maximization. The results revealed that the national estimated daily intake (NEDI) of iprodione was 2.0650 mg for general population, accounting for 54.6% of the acceptable daily intake, which demonstrated that the terminal residue of iprodione in shallot would not cause unacceptable risk to the health of the general population.

       

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