Abstract:
In order to find thiourea derivatives containing coumarin moiety with high antibacterial activities, thirteen 3-aryl-4-coumarinoxy phenylthiourea derivatives were synthesized. Their structures were characterized by IR,
1H NMR,
13C NMR, MS and elemental analysis, and their antibacterial activities against two pathogenic bacteria were preliminarily evaluated in this work. The results indicated that target compounds possessed good antibacterial activities. Among of them, compounds
4b ,
4h ,
4i ,
4j and
4m showed excellent antibacterial activities against
Xanthomonas oryzae pv.
oryzae with EC
50 value of 117.7, 118.1, 105.7, 104.3 110.5 μg/mL, respectively, which were all superior to that of thiodiazole-copper (EC
50 value 195.8 μg/mL). Meanwhile, compounds
4b ,
4h ,
4i ,
4j and
4m showed better antibacterial activities against
Xanthomonas citri subsp.
citri with EC
50 value of 111.6, 95.6, 102.9, 83.1, 112.1 μg/mL, respectively, which were superior to that of thiodiazole-copper (EC
50 value 128.7 μg/mL).