Abstract: Aegilops tauschii, a noxious weed, is widely distributed in winter wheat fields in China. The feasibility of pre-emergence (PRE) chemical control of A. tauschii was studied by the greenhouse and field experiments to find out appropriate PRE herbicides against A. tauschii and provide theoretical foundation for the chemical control of A. tauschii. The results of greenhouse study showed that flufenacet, oxadiazon and isoproturon were effective against A. tauschii, with GR₅₀ values of 37.2, 15.7 and 349.3 g/hm², respectively, which were all below their field recommended rates. However, their selectivity indexes (I_s) were below 2 (0.6-1.1), which suggested poor safety to wheat. The joint effect type was additive when isoproturon was mixed with oxadiazon for the control of A. tauschii. When the mass ratio was 4 : 1 (isoproturon : oxadiazon), the weed control efficacy of the mixtures against A. tauschii was higher than that of isoproturon applied alone, and the safety of the mixtures to tested wheat cultivars was improved when compared with that of oxadiazon or isoproturon used alone with I_s of 2.0. The results of the field experiments showed that the PRE application of the mixtures of isoproturon and oxadiazon at 600-900 g/hm² had 86% efficacy against Bromus japonicus, A. tauschii, Galium aparine and Descurainia sophia at least, increased wheat grain yield by at least 13%, and were safe to the test cultivar of winter wheat.