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明胶微球剂研究进展

张奇珍 尹明明 余曼丽 陈福良

张奇珍, 尹明明, 余曼丽, 陈福良. 明胶微球剂研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2021.0068
引用本文: 张奇珍, 尹明明, 余曼丽, 陈福良. 明胶微球剂研究进展[J]. 农药学学报. doi: 10.16801/j.issn.1008-7303.2021.0068
Qizhen ZHANG, Mingming YIN, Manli YU, Fuliang CHEN. Research progress of gelatin microspheres[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2021.0068
Citation: Qizhen ZHANG, Mingming YIN, Manli YU, Fuliang CHEN. Research progress of gelatin microspheres[J]. Chinese Journal of Pesticide Science. doi: 10.16801/j.issn.1008-7303.2021.0068

明胶微球剂研究进展

doi: 10.16801/j.issn.1008-7303.2021.0068
基金项目: 国家重点研发计划 (2016YFD0200500)
详细信息
    作者简介:

    张奇珍,女,硕士,主要从事农药制剂学研究,E­mail:18800178161@163.com

    通讯作者:

    陈福良,通信作者 (Author for correspondence),男,研究员,主要从事农药制剂学研究,E­mail:flchen@ippcaas.cn

  • 中图分类号: TQ450.6

Research progress of gelatin microspheres

  • 摘要: 基于传统农药剂型有效利用率低、持效期短以及过量使用和重复使用而引发的一系列环境污染及对非靶标生物危害等问题,发展高效、安全、控释的缓释剂型对农业可持续发展具有重大意义。天然高分子明胶因具有无毒无害、来源丰富、生物可降解、易成膜等特点已成为控释剂的理想载体,在生物、医学、农药等领域展现出良好的应用前景。本文重点论述了明胶微球剂的制备方法,并评述了其特点及不足。同时概述了明胶微球剂及与其他载体构成缓释体系的应用进展,从载药体系的粒径参数、缓释性能、药剂性质等方面进行了阐述。总结了近年来在农药、医药等领域明胶微球剂的研究及开发应用,分析了明胶微球剂存在的问题,对明胶微球剂未来在农药领域的发展方向进行了展望,以期为明胶微球剂的应用提供相关理论与技术参考。
  • 图  1  明胶的化学分子式

    Figure  1.  The chemical formula for gelatin

    图  2  呋虫胺明胶微球剂制备示意图[3]

    Figure  2.  Schematic diagram of preparation of dinotefuran gelatin microspheres[3]

    图  3  PCL/明胶/PVP微球剂不同浓度的明胶SEM图[29]

    Figure  3.  SEM images of PCL/gelatin/PVP microspheres with different concentrations of gelatin[29]

    表  1  药剂性质与制备方法对应图

    Table  1.   Corresponding diagram of chemical properties and preparation method

    制备方法 Preparation method       化合物性质 Compound properties      
    喷雾干燥法 Spray-drying method 亲水性及脂溶性 Hydrophilic and hydrophobic[18]
    冷冻干燥法 Freeze-drying method 温度敏感型 Temperature sensitive[19]
    O/O型溶剂挥发法 O/O solvent evaporation method 亲水性 Hydrophilic [20]
    O/W型溶剂挥发法 O/W solvent evaporation method 脂溶性 Hydrophobic [20]
    复乳化-溶剂挥发法 Double emulsion solvent evaporation method 亲水性及脂溶性 Hydrophilic and hydrophobic[21-22]
    乳化交联法 Emulsification crosslinking method 亲水性 Hydrophilic[23-24]
    相分离法 Phase separation method 温度敏感型 Temperature sensitive[18]亲水性 Hydrophilic[18]
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出版历程
  • 收稿日期:  2020-12-01
  • 录用日期:  2021-02-08
  • 网络出版日期:  2021-03-16

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