Abstract:
Validoxylamine A is an important biopesticide intermediate with bacteriostatic and insecticidal activities. To discover new green pesticides, 9 novel compounds were synthesized by lipase esterification reaction using validoxylamine A as the lead compound. Their structures were characterized by
ⅠH NMR,
13C NMR and HRMS. The biological activities results showed that most of those compounds retained their inhibitory activity against
Rhizoctonia solani. Compound
Ⅰ had the best inhibitory effect, with the EC
50 value of 13.03 μmol/L. Compound
Ⅶ had a lethality of 64.60% to
Aphis craccivora at 500 mg/L. This class of derivatives has fungicidal and insecticidal activities and is worthy of further study.