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20%异丙甲 • 苄泡腾片剂的研制及其对稻田杂草的防治效果

延卫垚 杨景涵 马英剑 秦敦忠 陈旺 陈志洋 冯建国

延卫垚, 杨景涵, 马英剑, 秦敦忠, 陈旺, 陈志洋, 冯建国. 20%异丙甲 • 苄泡腾片剂的研制及其对稻田杂草的防治效果[J]. 农药学学报, 2022, 24(3): 536-543. doi: 10.16801/j.issn.1008-7303.2022.0010
引用本文: 延卫垚, 杨景涵, 马英剑, 秦敦忠, 陈旺, 陈志洋, 冯建国. 20%异丙甲 • 苄泡腾片剂的研制及其对稻田杂草的防治效果[J]. 农药学学报, 2022, 24(3): 536-543. doi: 10.16801/j.issn.1008-7303.2022.0010
YAN Weiyao, YANG Jinghan, MA Yingjian, QIN Dunzhong, CHEN Wang, CHEN Zhiyang, FENG Jianguo. Preparation of metolachlor + bensulfuron-methyl 20% effervescent tablets and its control efficacy on weeds in paddy field[J]. Chinese Journal of Pesticide Science, 2022, 24(3): 536-543. doi: 10.16801/j.issn.1008-7303.2022.0010
Citation: YAN Weiyao, YANG Jinghan, MA Yingjian, QIN Dunzhong, CHEN Wang, CHEN Zhiyang, FENG Jianguo. Preparation of metolachlor + bensulfuron-methyl 20% effervescent tablets and its control efficacy on weeds in paddy field[J]. Chinese Journal of Pesticide Science, 2022, 24(3): 536-543. doi: 10.16801/j.issn.1008-7303.2022.0010

20%异丙甲 • 苄泡腾片剂的研制及其对稻田杂草的防治效果

doi: 10.16801/j.issn.1008-7303.2022.0010
基金项目: 江苏省大学生创新创业训练计划(202011117049Z);江苏省研究生科研与实践创新计划项目(SJCX21_1613).
详细信息
    作者简介:

    延卫垚,2798970967@qq.com

    通讯作者:

    冯建国,jgfeng@yzu.edu.cn.

  • 中图分类号: TQ450.6

Preparation of metolachlor + bensulfuron-methyl 20% effervescent tablets and its control efficacy on weeds in paddy field

Funds: the Innovation and Entrepreneurship Training Program for College Students in Jiangsu Province (202011117049Z), the Postgraduate Research &Practice Innovation Program of Jiangsu Province(SJCX21_1613).
  • 摘要: 为了提高稻田杂草化学防除的省力化程度,降低防治成本,通过单一变量法筛选配方中的助剂种类和用量,采用干法压片工艺制备了20%异丙甲 • 苄泡腾片剂 (有效成分异丙甲草胺 + 苄嘧磺隆),同时进行了田间药效评价。结果表明:20%异丙甲 • 苄泡腾片剂的优化配方(质量分数)为:16%异丙甲草胺,4%苄嘧磺隆,18%有机膨润土,9%白炭黑,20%酒石酸,20%碳酸氢钠,6%润湿剂EFW,4%分散剂G202和3%润滑剂硬脂酸镁。该泡腾片剂在有效成分120~180 g/hm2 的用量范围内能有效防除稻田杂草,防效明显优于其单剂,与已登记的20%异丙甲 • 苄(有效成分质量比17 : 3)可湿性粉剂相当,持效期达40 d以上。所研制的20%异丙甲 • 苄泡腾片剂表面光滑,无粉尘,使用方便,省时省工,对稻田常见杂草均有良好防效,持效期长,具有推广价值。
  • 图  1  泡腾片剂加工工艺流程

    Figure  1.  Process for the preparation of effervescent tablets

    图  2  不同填料的氮气吸附曲线

    Figure  2.  Nitrogen adsorption curves of different fillers

    表  1  不同填料的物理性质

    Table  1.   Physical properties of different fillers

    填料名称
    Fillers name
    颗粒间孔隙率Interparticle porosity,
    Ie
    流动性 (吸附原油后)Liquidity (After adsorption
    of crude oil)
    休止角Angle of
    repose, α/(°)
    豪斯纳比Hausner
    ratio, IH
    白炭黑 White carbon black 2.9 16 1.09
    高岭土 Kaolin clays
    1.0 25 1.31
    有机膨润土 Organobentonite
    1.1 22 1.22
    硅藻土 Kieselguhr
    0.4 29 1.36
    下载: 导出CSV

    表  2  填料选择

    Table  2.   Filler selection

    填料 (m (白炭黑) : m (有机膨润土) =)Fillers (m (silica) : m(organobentonite) =)崩解时间Disintegration
    time/s
    悬浮率Suspensibility/
    %
    硬度Hardness/
    (kg/mm2)
    13.5 : 13.541087.44.5
    18 : 940286.33.2
    9: 1841889.86.9
    下载: 导出CSV

    表  3  崩解剂选择

    Table  3.   Disintegrant selection

    崩解剂
    Disintegrant
    质量比
    Mass ratio
    崩解时间
    Disintegration time/s
    CO2 释放量Carbon
    dioxide release/g
    吸湿率Moisture absorption
    rate/%
    柠檬酸 : 碳酸钠
    Citric acid : sodium carbonate
    22 : 18 688 0.144 5.1
    21 : 19 650 0.141 5.0
    20 : 20 733 0.132 5.3
    19 : 21 750 0.136 5.1
    18 : 22 834 0.118 4.7
    柠檬酸 : 碳酸氢钠Citric acid :
    sodium bicarbonate
    22 : 18 998 0.082 5.1
    21 : 19 912 0.111 5.0
    20 : 20 860 0.129 5.3
    19 : 21 823 0.150 4.7
    18 : 22 821 0.142 4.9
    酒石酸 : 碳酸钠Tartaric acid :
    sodium carbonate
    22 : 18 680 0.158 5.9
    21 : 19 630 0.182 6.0
    20 : 20 621 0.189 6.3
    19 : 21 650 0.176 6.3
    18 : 22 745 0.134 6.1
    酒石酸 : 碳酸氢钠Tartaric acid :
    sodium bicarbonate
    22 : 18 521 0.161 5.3
    21 : 19 478 0.188 5.8
    20 : 20 407 0.202 5.9
    19 : 21 445 0.192 5.8
    18 : 22 500 0.168 5.6
    下载: 导出CSV

    表  4  润湿剂选择

    Table  4.   Wetting agent selection

    润湿剂
    Wetting agent
    质量分数
    Mass fraction/%
    润湿时间
    Wetting time/s
    790A 6 69
    十二烷基硫酸钠
    Sodium lauryl sulfate
    6 72
    木质素磺酸钠
    Sodium lignosulfonate
    6 69
    烷基萘磺酸盐 (EFW)
    Alkyl naphthalene sulfonate
    6 43
    下载: 导出CSV

    表  5  分散剂选择

    Table  5.   Dispersant selection

    分散剂
    Dispersant
    质量分数
    Mass fraction/%
    悬浮率
    Suspensibility/%
    十二烷基苯磺酸钠
    Sodium dodecyl benzene sulfonate
    4 83
    亚甲基双萘磺酸钠 NNO
    4 81
    羧酸盐分散剂 D1003
    Carboxylate D1003
    4 84
    分散剂 202 Greensperse 202 (G202)
    4 90
    下载: 导出CSV

    表  6  润滑剂选择

    Table  6.   Lubricant selection

    润滑剂
    Lubricant
    质量分数
    Mass fraction/%
    光滑度
    Smoothness
    是否黏冲Whether stick to
    the punch
    滑石粉
    Talcum
    3 不光滑
    Rough
    黏冲
    Punch sticking
    聚乙二醇6000PEG6000
    3 不光滑
    Rough
    不黏冲
    No punch sticking
    硬脂酸镁
    Magnesium stearate
    3 光滑
    Smooth
    不黏冲
    No punch sticking
    下载: 导出CSV

    表  7  包装材料选择

    Table  7.   Packaging material selection

    包装材料
    Packaging materials
    稳定性
    Stability
    水溶袋
    Water soluble bag
    密闭性差,不崩解
    Poor tightness, no disintegration
    PE袋
    PE bag
    密闭性差,不崩解
    Poor tightness, no disintegration
    铝箔袋
    Aluminum foil bag
    密闭性强,崩解
    Strong tightness, disintegration
    下载: 导出CSV

    表  8  热贮前后CO2释放量

    Table  8.   Release amount of CO2 before and after the thermal storage

    序号
    Serial number
    单片质量
    Tablet mass/g
    贮前释放 CO2 质量
    Mass of carbon dioxide before storage/g
    序号
    Serial number
    单片质量
    Tablet mass/g
    贮后释放 CO2 质量
    Mass of carbon dioxide after storage/g
    1 0.77 0.193 1 0.79 0.194
    2 0.79 0.196 2 0.78 0.196
    3 0.81 0.202 3 0.82 0.201
    4 0.80 0.198 4 0.81 0.200
    5 0.80 0.194 5 0.80 0.193
    下载: 导出CSV

    表  9  20%异丙甲 • 苄泡腾片热贮稳定性

    Table  9.   Thermal storage stability of metolachlor + bensulfuron-methyl 20% effervescent tablets

    检测项目
    Test items
    热贮前Before thermal
    storage
    热贮后After thermal
    storage
    异丙甲草胺含量
    The content of metolachlor/%
    16 15.4
    苄嘧磺隆含量
    The content of bensulfuron-methyl/%
    4 3.9
    悬浮率
    Suspensibility/%
    90 88
    pH 值
    pH value
    6.9 6.7
    崩解时间
    Disintegration time/s
    418 532
    是否胀袋
    Whether swollen bag

    No

    No
    下载: 导出CSV

    表  10  20%异丙甲 • 苄泡腾片剂对稻田杂草的株防效和鲜重防效

    Table  10.   The control efficacy of metolachlor + bensulfuron-methyl 20% effervescent tablets based on the weed number and fresh weight in rice fields

    防治效果 Control efficacy/%
    处理
    Treatment
    稗草
    Echinochloa crusgalli
    千金子
    Leptochloa chinensis
    鳢肠Eclipta prostrata
    莎草
    Cyperus rotundus
    总草
    Total grass
    药后 20 d 株防效
    Control efficacy of plant number after 20 d
    1 93.15 a 83.24 b 95.79 a 91.09 a 91.42 a
    2 96.04 a 89.21 a 97.47 a 92.38 a 94.05 a
    3 34.95 c 25.90 c 86.39 b 89.41 a 60.81 c
    4 87.64 b 82.43 b 83.45 b 83.84 b 84.32 b
    5 94.13 a 82.39 b 95.62 a 91.76 a 91.77 a
    药后 40 d 株防效
    Control efficacy of plant number after 40 d
    1 85.76 a 81.06 a 88.52 a 88.31 a 86.03 a
    2 87.62 a 81.36 a 93.35 a 91.06 a 88.90 a
    3 28.63 c 23.29 b 87.19 a 88.11 a 58.39 c
    4 79.18 b 80.71 a 79.74 b 85.12 b 81.82 b
    5 86.06 a 82.31 a 89.69 a 87.07 ab 86.35 a
    药后 40 d 鲜重防效
    Control efficacy of fresh weight after 40 d
    1 91.77 a 88.62 a 88.86 b 90.03 a 90.05 a
    2 94.97 a 90.78 a 94.57 a 92.37 a 93.19 a
    3 24.51 c 18.31 b 88.84 b 89.27 a 39.95 b
    4 86.93 b 88.49 a 81.06 c 86.95 b 86.45 a
    5 92.26 a 88.65 a 90.26 ab 86.57 b 90.22 a
    注:同列数值后含有不同字母表示邓肯新复极差检验法在P < 0.05水平上差异显著。处理1为20%异丙甲 • 苄泡腾片(有效成分120 g/hm2);处理2为20%异丙甲 • 苄泡腾片(有效成分180 g/hm2);处理3为10%苄嘧磺隆可湿性粉剂(有效成分120 g/hm2);处理4为960 g/L异丙甲草胺乳油(有效成分120 g/hm2);处理5为20%异丙甲 • 苄可湿性粉剂(有效成分120 g/hm2)。Note: Different letters in the same column mean significant differences at P < 0.05 according to a DMRT test. Treatment 1: metolachlor + bensulfuron-methyl 20% effervescent tablets (120 g a.i./hm2). Treatment 2: metolachlor + bensulfuron-methyl 20% effervescent tablets (180 g a.i./hm2). Treatment 3: bensulfuron-methyl 10% WP (120 g a.i./hm2). Treatment 4: metolachlor 960 g/L EC (120 g a.i./hm2). Treatment 5: metolachlor + bensulfuron-methyl 20% WP (120 g a.i./hm2).
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-01-22
  • 录用日期:  2021-12-07
  • 网络出版日期:  2022-02-09
  • 刊出日期:  2022-06-10

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