Abstract: In order to explore the application of new comb-type fluorine-containing polymer surfactants in the development of nitrosulfonone suspension concentrate, 25% nitrosulfonone suspension concentrates with different dispersants were prepared by taking such surfactants b1 and b9 as dispersants and commercial dispersant YUS-FS3000 as control. The physicochemical properties such as suspensibility, nominal size, dispersibility in water, and stability, biological activity in a greenhouse, and the effect of the addition amount of dispersant b1 on the above properties were measured respectively. The results showed that the active ingredient content was 25.52%-26.98% under the three conditions of 54 ℃, 0 ℃, and −18 ℃ for 14 days, which was qualified under the three conditions. At the same time, the suspensibility was higher than 98.0% under three storage conditions, and the suspension concentrate prepared by b1 was better than that by YUS-FS3000 as dispersant. Even if the addition amount (mass fraction) of b1 was 2%, the active ingredient content was between 25.62% and 26.01% after being stored for 14 days under three conditions. At the same time, the suspensibility was higher than 99.0% under three storage conditions. The GR₅₀ (50% growth reduction) values of 25% mesotrione aqueous suspension concentrate prepared by these three dispersants on Echinochloa crusgalli (L.) Beauv were 29.03 (YUS-FS3000), 15.70 ( b1 ) and 10.19 ( b9 ) g (a.i.)/hm², respectively.