Research progress on the function of plant pathogenic oxysterol binding protein and its targeted inhibitors

Oxysterol-binding protein (OSBP) and its homologous proteins (ORPs) constitute a conserved family of lipid-binding/lipid transfer proteins (LTPs), which are widely expressed in eukaryotic cells. It participated lipid metabolism, vesicle transport and signal transduction in organisms. Here, the structure and function of OSBPs are described systematically, and the targeted inhibitors based on OSBPs are reviewed too. It provided theoretical support and practical models for the rational design and application of pesticide based on new targets.