Synthesis and fungicidal activity of 5-(2-ethylcyclohexylidene)-2-aminoimidazolin-4-one derivatives

A series of new 5-(2-ethylcyclohexylidene)-2-aminoimidazolin-4-one derivatives 3a-3f were synthesized via Knoevenagel condensation,methylation and substitution reaction using 2-ethylcyclohexanone and 2-thiohydantoin as starting material.Their structures were confirmed by 1H NMR,IR and MS spectral data.The preliminary bioassay showed that some of the compounds have good fungicidal activity against Sclerotinia scleotiorum at the concentration of 50 μg/mL.The EC50 values of compound 3a,3c,3e and 3f against S.scleotiorum were 12.10,8.73,10.11 and 7.67 μg/mL, respectively.