黄朋勉, 周智慧, 吴鸿, 周玲, 丁慧, 伍斌, 赵东江, 黄超群. 环磺酮原药中3个杂质结构的确定及其合成[J]. 农药学学报, 2019, 21(2): 233-237. DOI: 10.16801/j.issn.1008-7303.2019.0032
    引用本文: 黄朋勉, 周智慧, 吴鸿, 周玲, 丁慧, 伍斌, 赵东江, 黄超群. 环磺酮原药中3个杂质结构的确定及其合成[J]. 农药学学报, 2019, 21(2): 233-237. DOI: 10.16801/j.issn.1008-7303.2019.0032
    shu
    HUANG Pengmian, ZHOU Zhihui, WU Hong, ZHOU Ling, DING Hui, WU Bin, ZHAO Dongjiang, HUANG Chaoqun. Characterization and synthesis of three impurities in tembotrione[J]. Chinese Journal of Pesticide Science, 2019, 21(2): 233-237. DOI: 10.16801/j.issn.1008-7303.2019.0032
    Citation: HUANG Pengmian, ZHOU Zhihui, WU Hong, ZHOU Ling, DING Hui, WU Bin, ZHAO Dongjiang, HUANG Chaoqun. Characterization and synthesis of three impurities in tembotrione[J]. Chinese Journal of Pesticide Science, 2019, 21(2): 233-237. DOI: 10.16801/j.issn.1008-7303.2019.0032
    shu

    环磺酮原药中3个杂质结构的确定及其合成

    Characterization and synthesis of three impurities in tembotrione

      摘要
    • 摘要: 采用文献中报道的环磺酮的合成工艺合成了环磺酮原药，通过高效液相色谱分析，发现其原药中含有3个质量分数分别大于0.1%的杂质；通过核磁共振氢谱 (1H NMR) 及高分辨质谱 (HRMS) 对3个杂质的结构进行了确证，同时进行了合成。根据合成工艺路线，对该杂质产生的途径进行了分析。

       

      Abstract: Tembotrione was prepared according to the reported method. Three main impurities over 0.1% were detected by high-performance liquid chromatography (HPLC). The structures of those impurities were characterized by 1H NMR and high resolution mass spectrometer (HRMS). Then the impurities were synthesized. The produced pathways of impurities were also analyzed according to the synthetic route.

       

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