Abstract: Flupyradifurone, a new butenolide insecticide developed by Bayer Cropscience AG, has excellent insecticidal activity against sucking pests. Compared with the existing commercial neonicotinoid insecticides, it has a unique mode of action and is low toxicity to bees. Therefore, it has been one of the hot research topics in the agrochemical field since it was launched in 2014. The creation process, bioactivity and resistance, mechanism of action, metabolic residue, effects on non-target organisms such as bees and structural modification of fluopyradifurone were summarized in this review.