毛玉帅, 段亚冰, 周明国. 琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展[J]. 农药学学报, 2022, 24(5): 937-948. DOI: 10.16801/j.issn.1008-7303.2022.0062
    引用本文: 毛玉帅, 段亚冰, 周明国. 琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展[J]. 农药学学报, 2022, 24(5): 937-948. DOI: 10.16801/j.issn.1008-7303.2022.0062
    MAO Yushuai, DUAN Yabing, ZHOU Mingguo. Research progress of the resistance to succinate dehydrogenase inhibitors[J]. Chinese Journal of Pesticide Science, 2022, 24(5): 937-948. DOI: 10.16801/j.issn.1008-7303.2022.0062
    Citation: MAO Yushuai, DUAN Yabing, ZHOU Mingguo. Research progress of the resistance to succinate dehydrogenase inhibitors[J]. Chinese Journal of Pesticide Science, 2022, 24(5): 937-948. DOI: 10.16801/j.issn.1008-7303.2022.0062

    琥珀酸脱氢酶抑制剂类杀菌剂抗性研究进展

    Research progress of the resistance to succinate dehydrogenase inhibitors

    • 摘要: 作用于琥珀酸脱氢酶复合体的新型杀菌剂-琥珀酸脱氢酶抑制剂 (succinate dehydrogenase inhibitors, SDHIs) 已逐步成为继Qo位点呼吸抑制剂类 (QoIs) 和麦角甾醇生物合成抑制剂类(EBIs)杀菌剂之后的世界第3大类杀菌剂。近年来,SDHIs杀菌剂的市场占有份额逐年增加,新品种不断涌现,在植物病害化学防治中发挥着重要作用。然而,由于该类杀菌剂作用位点单一,抗药性已成为制约该类杀菌剂创制发展与科学应用的重要科学问题。本综述归纳了琥珀酸脱氢酶抑制剂类杀菌剂的开发、品种、抗性发生发展、抗性分子机制与应用现状,并结合作者研究团队的最新研究成果对其靶标生物学及应用技术研究进行了总结,以期为更高活性的SDHIs杀菌剂创制和应用提供参考。

       

      Abstract: Succinate dehydrogenase inhibitors (SDHIs), targeting succinate dehydrogenase complex, have gradually become the third largest group of fungicides in the world after quinone outside inhibitors (QoIs) and ergosterol biosynthesis inhibitors (EBIs). In recent years, the market share of SDHIs is increasing yearly, and new members are emerging, playing a vital role in the chemical control of plant diseases. However, due to the single action site of these fungicides, fungicide resistance has become a key scientific issue that restricts the development and scientific application of these fungicides. In this paper, the development, products, occurrence and development of resistance, molecular mechanism and application status of SDHIs were reviewed. Together with the latest research achievements from the author's laboratory, the research on target biology and application technology was summarized, to provide references for the innovation and application of higher activity SDHIs.

       

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