Abstract:
In order to discover high antifungal activity oxime esters compound, based on our previous studies, 18 novel coumarin oxime esters were designed and synthesized. The antifungal activity was evaluated and the structure-activity relationship was analyzed. The
in vitro bioassay results showed that the target compounds showed antifungal activities against
Botrytis cinerea,
Valsa mali and
Rhizoctonia solani. Especially, compound
4n displayed excellent activity against
B. cinerea (EC
50 = 4.44 μg/mL) and
R. solani (EC
50 = 3.65 μg/mL), which are better than or similar to those of coumarin and trifloxystrobin.