植物病原菌氧化固醇结合蛋白的功能及其靶向抑制剂研究进展

Research progress on the function of plant pathogenic oxysterol binding protein and its targeted inhibitors

摘要: 氧化固醇结合蛋白 (OSBP) 及其同系物(ORPs)共同构成脂质结合/转移蛋白 (LTPs) 的保守家族，它们在真核生物细胞中广泛表达，主要作用是参与细胞中的脂类代谢、囊泡运输及信号转导等方面。本文主要对植物病原菌中氧化固醇结合蛋白的结构、功能等进行系统阐述，并对基于氧化固醇结合蛋白的靶向抑制剂的设计合成工作进行综述，可为基于新靶标农药的合理设计与应用提供理论支撑。

Abstract: Oxysterol-binding protein (OSBP) and its homologous proteins (ORPs) constitute a conserved family of lipid-binding/lipid transfer proteins (LTPs), which are widely expressed in eukaryotic cells. It participated lipid metabolism, vesicle transport and signal transduction in organisms. Here, the structure and function of OSBPs are described systematically, and the targeted inhibitors based on OSBPs are reviewed too. It provided theoretical support and practical models for the rational design and application of pesticide based on new targets.