Abstract: Natural product-derived botanical insecticides have the advantages of strong target specificity, easy degradation, pesticide residue free and no pollution to the environment compared to the traditional chemical insecticides. They meet the development requirements of green agriculture and are one of the important research and development fields of insecticides. In this paper, the current status of the research and development of botanical natural product insecticides as lead compounds for structural modification since 2015 were reviewed. Finally, the trends of future development, current challenges and the subsequent research strategy of botanical insecticides were analyzed and prospected.