Abstract:
A series of 20 novel acylsulfonimide derivatives
3a-3t were synthesized from phthalic anhydride, sulfonamide and butyl chloroformate by means of active substructure splicing. Their structures were confirmed by
1H NMR,
13C NMR and high resolution mass spectrometry. The fungicidal and herbicidal activities of the target compounds were determined using the mycelial growth rate method and the stem and leaf spray method, respectively. The results of fungicidal activity showed that most of the compounds had good inhibitory effects against
Sclerotinia sclerotiorum,
Colletotrichum camalliae,
Sclerotium rolfii and
Phytophthora capsici at 50 mg/L. The inhibition rates of
3f,
3n and
3q against
S. sclerotiorum were 63.98%, 79.56% and 77.83%, respectively, which were better than that of the commercial asulox (58.78%). The EC
50 values of compound
3q against
C. camalliae and
S. sclerotiorum were 21.57 mg/L and 10.49 mg/L, respectively, which were better than asulox. The herbicidal activity results showed that, the fresh weight control effect of compound
3a against
Echinochloa crus-galli was 52.48% at 150 mg/L, which was lower than asulox (71.68%). The novel compounds synthesized in this study displayed fungicidal activities, which can provide reference for the study of biological activities of novel acyl sulfonimide derivatives.