Abstract: The basic principles of quantitative structure activity relationship(QSAR)was introduced, The paper put emphasis on the main principles, the advance of research and application of QSAR analysis methods for pesticide design, as well as their advantage and disadvantage, including Hansch, Free-Wilson, Molecular orbitial (MO), Distance Comparisons (DISCO), Comparison molecular field analysis (CoMFA), Molecular similarity (MS), Molecular dock (MD), Artificial naural network(ANN), and Leapfrog methods. Some suggestions were provided for QSAR.