α-甲硫基环十二酮肟酯的合成及除草活性

The Synthesis of α-Methylthiocyclododecanone Oxime Esters and Herbicide Activity

摘要: 以环十二酮为原料,经α-甲硫基环十二酮肟合成了16个新的α-甲硫基环十二酮肟酯,其结构经元素分析、1H NMR、13C NMR和IR 的确证。初步生测结果表明,部分化合物对马唐Digitaria sanguinalis(Linn.)Scopoli和苘麻Abutilon theophrasti Medic具有较好的除草活性,其中 G7 在100 mg/L 时对马唐、苘麻的抑制率均为100%,在1 mg/L时其抑制率分别为84.3%和89.0%,相同浓度下与对照药剂乙草胺的活性相当。精密毒力测定结果表明, G7 对马唐和苘麻的IC50值分别为0.208和0.024 mg/L。

Abstract: Sixteen new α-methylthiocyclododecanone oxime esters were synthesized by the reaction of acylation of α-methylthiocyclododecanone oxime as intermediate with acids. Their structures were confirmed by elemental analysis,1H NMR, 13C NMR and IR spectral data. The preliminary bioassay results showed that some of compounds have good herbicidal activities against Digitaria sanguinalis(Linn.)Scopoli and Abutilon theophrasti Medic. The inhibition rate of G7 against D. sanguinalis and A. theophrasti were 100% and 100% at 100 mg/L,while G7 against D. sanguinalis and A. theophrasti 84.3% and 89.0% at 1 mg/L. The IC50 values of G7 against D. sanguinalis and A. theophrasti are 0.208 and 0.024 mg/L,respectively.