Abstract: In order to clear the prospects of stilbene compounds in agricultural disease prevention and treatment,effects of resveratrol (Ⅰ)and its derivatives (Ⅱ-Ⅴ )on mycelial growth,mycelial morphology,and spore germination were tested in vitro and disease prevention principles were studied in vivo by using leaf method and pot-culture method.Results showed that 5 tested compounds had different degrees of inhibition effects on mycelial growth of 6 tested pathogens,especially to A.solani,in which 3,5-dihydroxy-4'-methoxy-stilbene (Ⅲ) showed higher inhibitory activity than other compounds.Resveratrol caused mycelial malfornation and inhibited the spore germination with no changes in morphology of A.solani.There was a conclusion that resveratrol can inhibit the infection of A.solani and play a protective action in vivo.