Progress on the Synthesis of Novel Hydantocidin Analogues

Hydantocidin is the first natural spiro-nucleoside which was isolated from the culture broth of Streptomyces hygroscopicus SANK 63584.It exhibited potential herbicidal activity with efficiency similar to glyphosate against lots of weeds with high selective toxicity between plants and animals.Recently,the novel hydantocidin analogues including carbohydrate,deoxy,cyclopeptide,and hybrid analogues were synthesized and their activity was assayed.The progress on the research of these novel hydantocidin analogues was reviewed.