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致病杆菌属细菌代谢物抑菌活性研究进展

韩云飞 他永全 王勇 冯俊涛 王永红

韩云飞, 他永全, 王勇, 冯俊涛, 王永红. 致病杆菌属细菌代谢物抑菌活性研究进展[J]. 农药学学报, 2022, 24(2): 217-231. doi: 10.16801/j.issn.1008-7303.2021.0192
引用本文: 韩云飞, 他永全, 王勇, 冯俊涛, 王永红. 致病杆菌属细菌代谢物抑菌活性研究进展[J]. 农药学学报, 2022, 24(2): 217-231. doi: 10.16801/j.issn.1008-7303.2021.0192
HAN Yunfei, TA Yongquan, WANG Yong, FENG Juntao, WANG Yonghong. Advances in antimicrobial substances from genus Xenorhabdus[J]. Chinese Journal of Pesticide Science, 2022, 24(2): 217-231. doi: 10.16801/j.issn.1008-7303.2021.0192
Citation: HAN Yunfei, TA Yongquan, WANG Yong, FENG Juntao, WANG Yonghong. Advances in antimicrobial substances from genus Xenorhabdus[J]. Chinese Journal of Pesticide Science, 2022, 24(2): 217-231. doi: 10.16801/j.issn.1008-7303.2021.0192

致病杆菌属细菌代谢物抑菌活性研究进展

doi: 10.16801/j.issn.1008-7303.2021.0192
基金项目: 国家自然科学基金(32072474);国家重点研发计划(2017YFD0201203).
详细信息
    作者简介:

    韩云飞,hanyunfei@nwafu.edu.cn

    通讯作者:

    王永红,yhwang@nwafu.edu.cn.

  • 中图分类号: S476.1;S482.292

Advances in antimicrobial substances from genus Xenorhabdus

Funds: the National Natural Science Foundation of China (32072474), the National Key Research and Development Program of China (2017YFD0201203).
  • 摘要: 致病杆菌属 (Xenorhabdus) 细菌是一类存在于昆虫病原线虫肠道内的共生菌,能够产生多种具有不同生物活性的次级代谢产物,其中一些化合物具有开发成为新农药的潜力。本文综述了致病杆菌属细菌中可产生抑菌活性物质的代表性菌株,较为全面地总结了近几十年来在致病杆菌属细菌代谢物中发现的抑菌活性化合物;对致病杆菌属细菌产生的部分抑菌活性化合物的抑菌作用机理进行了讨论,认为影响蛋白质合成是某些化合物发挥抑菌作用的重要途径。基于抑菌活性化合物的生物合成途径及相关调控因子,总结了从致病杆菌属细菌代谢物中发掘新化合物和提高特定活性化合物产量的方法。针对现阶段致病杆菌属细菌及其次级代谢产物研究应用中存在的问题提出了相应的对策,并简要概述了未来致病杆菌属细菌的研究发展方向。本文可为如何合理有效利用致病杆菌属细菌活性代谢物提供参考,对于促进致病杆菌属细菌及其次级代谢产物的应用具有重要意义。
  • 图  1  嗜线虫致病杆菌YL001初生型菌株在NBTA培养基上的形态特征

    Figure  1.  Characteristics of primary phenotypic X. nematophila YL001 on NBTA medium

    图  2  致病杆菌属细菌产生的抑菌活性化合物 (1~25)

    Figure  2.  Antimicrobial compounds (1-25) produced by genus Xenorhabdus

    图  3  致病杆菌属细菌产生的多肽类抑菌活性化合物 (26~54)

    Figure  3.  Polypeptide antimicrobial compounds (26-54) produced by genus Xenorhabdus

    图  4  致病杆菌属细菌产生的酰胺类及其他抑菌活性化合物 (55~64)

    Figure  4.  Amides and others antimicrobial compounds (55-64) produced by genus Xenorhabdus

    表  1  致病杆菌属细菌发酵液的抑菌活性

    Table  1.   Antimicrobial activities of the fermentation liquid of genus Xenorhabdus

    菌株     
    Strains     
    菌株发现地  
    Places of Xenorhabdus discovered  
    抑菌谱 
    Bacteriostatic spectrum 
    文献
    References
    伯氏致病杆菌 YL002
    Xenorhabdus bovienii YL002
    中国杨凌
    Yangling, China
    真菌、细菌、卵菌
    Fungi, bacteria, oomycetes
    [11]
    Xenorhabdus budapestensis C72 中国北京
    Beijing, China
    真菌
    Fungi
    [27]
    Xenorhabdus cabanillasii 土耳其
    Turkey
    真菌
    Fungi
    [28]
    Xenorhabdus doucetiae IBSC n15 巴西
    Brazil
    真菌
    Fungi
    [29]
    Xenorhabdus khoisanae J194 南非
    South Africa
    细菌
    Bacteria
    [30]
    Xenorhabdus khoisanae SB10 南非
    South Africa
    真菌、细菌
    Fungi, bacteria
    [31]
    嗜线虫致病杆菌 CB6
    Xenorhabdus nematophila CB6
    中国北京
    Beijing, China
    真菌、细菌、卵菌
    Fungi, bacteria, oomycetes
    [14, 32]
    嗜线虫致病杆菌 YL001
    Xenorhabdus nematophila YL001
    中国杨凌
    Yangling, China
    真菌、细菌、卵菌
    Fungi, bacteria, oomycetes
    [11, 17]
    Xenorhabdus romanii CER129 巴西
    Brazil
    真菌
    Fungi
    [29]
    Xenorhabdus sp. strain Q1 澳大利亚
    Australia
    真菌、细菌
    Fungi, bacteria
    [4]
    Xenorhabdus szentirmaii DSM 16338 阿根廷
    Argentina
    真菌
    Fungi
    [33]
    下载: 导出CSV
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  • 收稿日期:  2021-09-27
  • 录用日期:  2021-11-04
  • 网络出版日期:  2021-12-24
  • 刊出日期:  2022-04-01

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