Abstract: Organosilicone tank-mixed adjuvants are a class of pesticide adjuvants widely used in agriculture with excellent wettability, penetrability, and spreadability. They show significant synergies and effectively improve the utilization rate of pesticides after spraying with pesticides. However, a large number of studies have shown that organosilicone tank-mixed adjuvants have different degrees of ecotoxicological risks to non-target organisms such as bees, natural enemy insects, and aquatic organisms. In addition, it’s worth noting that methoxy-terminated trisiloxane ethoxylate has potential endocrine-disrupting effects. This review introduced the composition, properties, and applications of organosilicone tank-mixed adjuvants, focused on their residue levels, toxicological risks, and analytical methods of the typical composition in different matrixes, summarized the management statuses of tank-mixed adjuvants at home and abroad and preliminarily analyzed the environmental risks of tank-mixed adjuvants. These comments would provide some reference to the systematic management and risk assessment of tank-mixed adjuvants in China.