Abstract: In sustainable agricultural production, an efficient and environmentally-friendly nano-drug carrier system is a considerably efficient way to enhance the efficacy of pesticides and minimize ecological side effects. In this study, tetraethyl orthosilicate (TEOS) was used as the silicon source with ammonia as the catalyst for the synthesis of hollow mesoporous silica (HMS) by a self-template method. HMS was loaded with emamectin benzoate (EB) by co-solvent method to prepare nano-drug carrier system (HMS-EB). Chitosan (CS) was covalently modified on the surface of HMS-EB to obtain a good foliage adhesion nano-drug carrier system (CS@HMS-EB). Results showed that the prepared CS@HMS-EB had a regular spherical shape and uniform particle size, with an average particle size of about 200 nm and a drug loading rate of 45.3%. Through the covalent interaction, CS successfully adhered to the surface of HMS-EB, which significantly improved the wetting, adhesion and retention capacity of EB on the surface of maize leaves. Moreover, under UV-light irradiation, the degradation rate of EB loaded in the CS@HMS-EB decreased by 40% compared with EB alone. Meanwhile, CS@HMS-EB had a good sustained release property. Importantly, Both indoor and field bioactivity evaluation assays showed that compared with commercial 5% emamectin benzoate microemulsion (EB ME), CS@HMS-EB exhibited higher insecticidal activity against Spodoptera furgiperda larvae. This nano-drug carrier system does not contain organic solvents and has good insecticidal activity, which is expecting to play a broad application prospect in pest control.