Abstract:
To enrich cinnamaldehyde's structure and discover highly active antifungal compounds, 27 novel cinnamaldehyde oxime esters were designed and synthesized. The antifungal activities of the target compounds against
Rhizoctonia solani,
Botrytis cinerea, and
Gaeumannomyces graminis were determined by the mycelium growth rate method. The target compounds showed certain inhibitory activity against the tested pathogenic fungi under 50 μg/mL. The EC
50 values of compounds
II-18 and
II-19 against
Rhizoctonia solani were 4.62 and 4.19 μg/mL, respectively. Furthermore, the EC
50 valuesof
II-18,
II-19 and
II-22 against
Gaeumannomyces graminis were 3.49, 3.28 and 6.75 μg/mL, respectively, which showed superior or comparable antifungal activities to those of 4-chlorocinnamaldehyde and trifloxystrobin.