Abstract: With the emergence and widespread use of insecticides, the resistance of pests to insecticides has increased. To develop efficient, low toxicity, and environmentally friendly insecticides to address the threat of pest resistance, this work adopts the method of active substructures splicing and uses cyproflanilide as the lead compound to design and synthesize 18 novel m-diamide compounds containing thioether, sulfoxide, and sulfone. All compounds were characterized by ¹H NMR and HRMS and some representative compounds were selected for ¹³C NMR characterization to further confirm their structures. Most target compounds exhibited excellent insecticidal activity against Nilaparvata lugens, especially 12d at 100 mg/L showing 87.32% activity against N. lugens. At the same time, some compounds also showed good activity against Tetranychus cinnabarinus, among which 10f showed 100.00% activity against T. cinnabarinus at a concentration of 10 mg/L. Based on the bioassay activity, preliminary structure-activity relationships were also discussed.