Abstract: By evaluating the combined dietary exposure risk of difenoconazole and pyraclostrobin on apple, the applicability of the combined exposure risk assessment method for multiple pesticide residues recommended by the European Union was investigated. The results showed that for the general population, the chronic dietary exposure risk quotient (cRQs) of difenoconazole and pyraclostrobin were 26.0% and 19.7%, and the acute dietary exposure risk quotient (aRQs) were 2.5% and 0.5%, respectively. The combined chronic cumulative exposure risk quotient was 31.4%, and the combined acute cumulative dietary exposure risk quotient was 6.4%. For the children group, the cRQs of difenoconazole and pyraclostrobin (average of males and females) were 56.0% and 40.0%, and the aRQs were 8.7% and 1.7%, respectively. The combined risk quotient of chronic cumulative dietary exposure was 66.9%, and the combined acute cumulative dietary exposure risk quotient was 22.4%. All dietary risk assessment values were within the acceptable limits. The study further analyzed the uncertainties influencing the assessment outcomes, suggesting that refining the quality of pesticide residue data and food consumption survey data would significantly enhance the reliability of the risk assessment results.