Abstract: Chiral pesticides, consisting of one or more groups of enantiomers, often exhibit significant differences in enantioselective effects in terms of biological activity, toxicity, and environmental behavior, thus triggering widespread concern and discussion. Bees are economically crucial insects that play an important role in crop pollination and biodiversity conservation. The effects of pesticides on bee health have become a major focus of global research; however, studies evaluating the impacts of chiral pesticides on bees at the stereoisomeric level remain limited, and a systematic summary of the existing findings is still lacking. Given this, this paper reviews the existing literature on representative chiral pesticides, including neonicotinoids, pyrethroids, and triazoles. We aim to systematically elucidate the stereoselective effects of these compounds on bees and summarize their selective degradation characteristics in honey- or pollen-source plants, thereby highlighting the potential exposure pathways for bees following application. We hope this review will provide valuable insights for the environmental risk assessment of chiral pesticides and offer guidance for the development and application of beneficial enantiomers.