Abstract: One primary approach for developing novel green pesticides is to discover agroactive lead compounds from natural products and modify their structures. In this study, a series of diphenylnorbornane derivatives were designed and synthesized using natural norbornane as a lead compound. Bioactivity results showed that the 22 synthesized target compounds displayed certain bioactivities against the tested plant pathogens at 50 μg/mL. Compounds 4a and 10d exhibited inhibition rates ranging from 80.5% to 100% against Botrytis cinerea, Fusarium graminearum, Phytophthora capsici, Rhizoctonia solani, Fusarium oxyspirum, Sclerotinia sclerotiorum and Valsa mali. Notably, their EC₅₀ values against B. cinerea were 3.31 and 4.02 μg/mL, respectively. Compounds 4a and 10d have characteristics of simple structures, good activity, and broad fungicidal spectrum. These compounds show potential as promising lead compounds for in-depth structural optimization research of fungicides.