Abstract: Twenty four novel methoximinoacetate compounds containing phenylpyridine moieties were synthesized from (3-hydroxyphenyl)boric acid and substituted bromopyridines via Suzuki cross-coupling reaction and nucleophilic substitution. The structures of all compounds were confirmed by H NMR, ESI-MS and IR. Bioactivity tests showed that most of the compounds have moderate to good fungicidal activity and compounds 5i , 5r and 5t exhibited more than 80% inhibition against Pseudoperonospora cubensis at 50 mg/L, which means that the title compounds are potential as the fungicidal lead compounds.