Abstract: Acylation of 2-amio-5-aryl-1,3,4-oxadiazoles with acyl chlorides and trichloroacetic acid to afford eleven new -N--5-aryl-1,3,4-oxadiazol-2-yl-substituted amides. The required oxadiazole precursors are prepared by oxidative cyclization of corresponding aldehyde semicarbazones. The structures of the synthesized compounds are elucidated by elemental analysis、 1HNMR、IR and MS. They are screened for their larvicidal activities against wild fruit and antibiotic activities.