Abstract: Nereistoxin insecticides as new biomimetic insecticides which were developed in the 1960s have been widely used for preventing and eliminating pest in rice,vegetable and fruit field as its high-effectiveness,low-toxicity and low-residue.In order to give an overview of significance of nereistoxin compounds with insecticidal activities,the structures and biological of nereistoxin,guinesines derivatives are introduced,which are classed according to the different types of pharmacophores.