喹唑啉衍生物的合成及农药生物活性研究进展

Recent advances on the synthesis and pesticidal activity evaluations of quinazoline derivatives

摘要: 喹唑啉衍生物具有广泛的农药生物活性，如抗细菌、抗真菌、杀虫、除草、抗病毒及杀螨等，近年来受到越来越多的关注。将不同药效团引入到喹唑啉骨架中，经结构修饰后能合成一系列具有农药生物活性的新型喹唑啉衍生物。本文综述了2000年以来喹唑啉衍生物的合成及农药活性研究进展，旨在为喹唑啉结构的修饰改造提供参考。

Abstract: Quinazoline derivatives, an important structure in drug discovery, have attracted increasing attention from the pharmaceutical researchers because of their various pesticidal activities such as antibacterial, antifungal, insecticidal, herbicidal, antiviral and acaricidal activities. Introducing different pharmacophores into quinazoline framework can afford a series of quinazoline derivatives which possesses better pesticidal activities. This paper reviewed the study on the synthesis and pesticidal activities of the quinazoline derivatives from year 2000 to 2016.