Abstract: In order to discover novel heterocyclic compounds with biological activity, six novel 1,3,4-thiadiazole amide derivatives containing benzimidazole moiety were synthesized under microwave assisted condition via etherification, condensation, hydrocarbylation and the ammonolysis reactions with substituted phenol and chloracetic acid as raw materials. The structures were confirmed by IR and 1H NMR. Fungicidal activity test showed that all the compounds exhibit fungicidal activity against the five fungi tested at the concentration of 50 mg/L, among them, the inhibition rate of 7c, 7d, 7e and 7f against the fungi tested were above 80%.