Abstract: A rapid and sensitive analytical method for the determination of LH-2010A residues in potato and soil was established based on QuEChERS(Quick, Easy, Cheap, Effective, Rugged and Safe) and high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The samples were extracted with acetonitrile, and purified with primary secondary amine (PSA) and octadecylsilane (C18). The mass spectrometer was performed in multi-reaction monitoring mode, and electrospray ionization in positive mode was selected. The LH-2010A residues were quantified by the external standard method using the matched standard solution to compensate for matrix effect. The results indicated that the calibration curves of LH-2010A were linear in the range of 0.002-1 mg/L with correlation coefficients of more than 0.999 9. When the addition level ranged from 0.005 to 0.5mg/kg, the intra-day average recoveries of LH-2010A in potato, potato plant and soil were 81%-98%, and the relative standard deviation (RSD) ranged from 2.2% to 13% (n = 5). The inter-day average recoveries of LH-2010A were 75%-106%, and with RSD ranged from 0.6% to 11% (n = 15). The limit of quantitation (LOQ) were 0.001 mg/kg in different matrices. This method is simple, rapid and accurate, and can be adapted for the confirmation of LH-2010A residues in potato samples.