Abstract: A rapid, simple and efficient analytical method for the determination of chlorantraniliprole in different primary grain and oilseed crops including brown rice, wheat, maize and soybean was developed and validated based on QuEChERS and high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Chlorantraniliprole residues were extracted from primary grain and oilseed crops samples using acetonitrile-water with the addition of sodium chloride. After centrifugation, the upper solvent was cleaned-up by N-propylethyl-diamine (PSA) and graphitizing of carbon black (GCB), and determined by HPLC-MS/MS under multiple reaction monitoring mode (MRM). Sample matrix-matched calibrations were used to determine the residue contents by external standard. The calibration curves showed a good linearity in the concentration range of 0.005-0.5 mg/L for chlorantraniliprole in different sample matrix. The determination coefficients (R²) of the calibration curves were all above 0.99 and the limit of detection (LOD) was 0.001 mg/L. At fortification levels of 0.02, 0.05, 0.1 and 0.5 mg/kg in different primary grain and oilseed crop samples, recoveries ranged from 89% to 114% with relative standard deviation (RSD) of 1.3% to 11% (n = 5). The limit of quantification (LOQ) of chlorantraniliprole in brown rice, wheat, maize and soybean were all 0.02 mg/kg. This new method is applicable to detect the residues of chlorantraniliprole in different primary grain and oilseed crops.