含单氟甲氧基的双酰胺类化合物的合成及杀虫活性

Synthesisandinsecticidalactivitiesofdiamidescontainingmonofluoromethoxygroup

摘要: 以2,3-二氯吡啶为起始原料，经肼基化、环合、氧化、取代、水解、环合和胺解反应，合成了15个文献未见报道的新型含单氟甲氧基的吡唑邻甲酰氨基苯甲酰胺类化合物，其结构通过核磁共振氢谱和高分辨质谱确认。初步的杀虫活性测试结果显示，所有目标化合物在100 mg/L下对粘虫Oriental armyworm的致死率均为100%，当测试浓度降低至4 mg/L时，化合物 8a 、 8d 、 8g 、 8k 和 8n 的致死率仍为100%，值得进一步研究。

Abstract: Fifteen novel diamides containing monofluoro methoxy group compounds were synthesized using 2,3-dichloropyridine as the starting material by hydrazinolysis, cyclization, oxidation, substitution, hydrolysis, cyclization and amine hydrolysis. The structures of the title compounds were characterized by ¹H NMR and HRMS. Preliminary bioassay results indicated that all the target compounds showed insecticidal activities. At the concentration of 100 mg/L, all compounds exhibited 100% insecticidal activities against Oriental armyworm. When the concentration was reduced to 4 mg/L, compounds 8a , 8d , 8g , 8k and 8n still exhibited 100% insecticidal activities against O. armyworm.