Abstract: Field experiments were conducted to evaluate cotton aphids (Aphis gossypii Glover) control efficacy of insecticides spray drone, MG-1S unmanned aerial vehicle (UAV).The results showed that control efficacy of 22% sulfoxaflor SC at 225 mL/hm² was better than 70% acetamiprid WG at 60 g/hm² and 70% imidacloprid WG at 30 g/hm². The adjuvant Gaogongxiao at 15 mL/hm² was recommended for optimum cotton aphid control in combination with 70% acetamiprid WG at 60 g/hm² and 70% imidacloprid WG at 30 g/hm². Flight control synergist at 150 mL/hm² could be co-applied with 22% sulfoxaflor SC at 150 mL/hm², following by the adjuvants of mineral oil, silicone and polymer additives.There was no significant difference between UAV spraying and tractor machine and manual tow spraying on the control efficacy of cotton aphid at the 3rd and 5th days after the application. However, UAV field application could decrease the spray volume of pesticides by 1/3, increase work efficiency by 3 times, and reduce the labor cost by 60 yuan/hm². UAV could meet the needs of modern agriculture and achieve efficiency increasing , pesticide saving and cost reduction.