中国农药创制概述与展望

芦志成; 张鹏飞; 李慧超; 关爱莹; 刘长令

doi:10.16801/j.issn.1008-7303.2019.0086

中国农药创制概述与展望

doi: 10.16801/j.issn.1008-7303.2019.0086

沈阳中化农药化工研发有限公司，新农药创制与开发国家重点实验室，沈阳 110021

基金项目: 国家重点研发计划 (2016YFD0300709)

详细信息

作者简介:
芦志成，男，助理工程师，主要从事新农药创制，E-mail：luzhicheng@sinochem.com

通讯作者:
关爱莹，共同通信作者 (Co-author for correspondence)，女，高级工程师，主要从事新农药创制，E-mail：guanaiying@sinochem.com

刘长令，通信作者 (Author for correspondence)，男，教授级高级工程师，主要从事新农药创制，E-mail：liuchangling@vip.163.com

中图分类号: TQ450.1
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出版历程
- 收稿日期: 2019-08-14
- 录用日期: 2019-08-27
- 刊出日期: 2019-12-01

Overview and prospect of agrochemical discovery in China

Shenyang Sinochem Agrochemicals R&D Co., Ltd., State Key Laboratory of the Discovery and Development of Novel Pesticide, Shenyang 110021, China

摘要

摘要: 中国是农业大国，而现代农业生产离不开农药。中国的农药工业经过近70年的发展，已从仿制国外品种到仿创结合再到自主创新的道路上逐渐发展壮大起来。在建国70周年之际，本文简要总结了中国农药创制的发展历史，对中国现有大多数农药创制品种从其化学结构、性能、创制经纬、作用机理以及专利和登记情况进行了介绍，并做了进一步的展望。
- 农药创制 /
- 农药品种 /
- 自主创新
Abstract: China is a big agricultural country, and modern agricultural production can not do well without agricultural chemicals. After nearly 70 years of development, China's pesticide industry has gradually developed from imitation of foreign varieties to combination of imitation and independent innovation. On the occasion of the 70th anniversary of the founding of China, this paper briefly summarizes the development history of agrochemicals discovery in China, and the structure, performance, discovery process, mode of action, patent and registration, and further prospect of most pesticides discovered and developed in China are also introduced.
- agrochemicals discovery /
- pesticide products /
- independent innovation

HTML全文

1 中国专利法实施前部分农药代表品种

1. Representative pesticides before the implementation of the patent law of China

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表 1 中国创制或开发农药一览表

Table 1. List of pesticide discovered or developed in China

农药种类 Classification of pesticide	中(英)文名称 Chinese (English) name	CAS 号 CAS registry number	专利申请日 Date of filing	原(母)药登记号 Drug registration number
杀菌剂(含杀细菌剂和抗病毒剂) Fungicides (including bactericides and virucides)	金核霉素 aureonuclemycin^b	123970-01-4	1987-03-18	LS20021932 (过期 overdue)
	宁南霉素 ningnanmycin^b	156410-09-2	1993-04-23	PD20097120
	氟吗啉 flumorph^a	211867-47-9	1996-08-21	PD20060039
	烯肟菌酯 enoxastrobin^a	238410-11-2	1998-02-10	PD20070339
	烯肟菌胺 fenaminstrobin^a	366815-39-6	2000-02-24	PD20095214
	噻菌铜 thiodiazole-copper^b	3234-61-5	1999-01-11	PD20086025
	噻唑锌 zinc-thiazole^b	3234-62-6	2000-12-15	PD20160049
	啶菌噁唑 pyrisoxazole^a	847749-37-5	1999-07-14	PD20080773
	氰烯菌酯 phenamacril^b	39491-78-6	2001-05-08	PD20121663
	长川霉素 ascomycin^b	104987-12-4	2001-10-08	LS20072567 (过期 overdue)
	申嗪霉素 phenazino-1-carboxylic acid	2538-68-3	2002-02-08	PD20110314
	苯醚菌酯 ZJ-0712	852369-40-5	2003-03-25	PD20151573
	氟唑活化酯 B2-a	864237-81-0	2003-05-16	LS20150091 (过期 overdue)
	丁吡吗啉 pyrimorph^b	868390-90-3	2003-07-01	PD20181610
	丁香菌酯 coumoxystrobin^a	850881-70-8	2003-11-11	PD20161260
	唑菌酯 pyraoxystrobin^a	862588-11-2	2004-02-20	PD20181599
	唑胺菌酯 pyrametostrobin^a	915410-70-7	2005-05-26	LS20110235 (过期 overdue)
	氯啶菌酯 triclopyricarb^a	902760-40-1	2005-02-06	PD20161257
	毒氟磷	882182-49-2	2005-04-04	PD20160339
	甲噻诱胺 methiadinil^b	908298-37-3	2006-02-20	PD20170015
	补骨脂种子提取物 isobavachalcone^b	20784-50-3	2008-01-25	PD20190058
	氟醚菌酰胺 fluopimomide^a	1309859-39-9	2010-09-07	PD20170010
杀虫剂(含杀螨剂) Insecticides (including acaricides)	苦皮藤素 celangulin^b	139979-81-0	1992-11-19	PD20101575
	硝虫硫磷 89-1	171605-91-7	1993-01-12	PD20080777
	氯胺磷 chloramine phosphorus^b	73447-20-8	1997-06-24	LS20051337 (过期 overdue)
	氟螨 F1050	259726-10-8	1997-12-15	LS20031728 (过期 overdue)
	硫肟醚 sulfoxime^b	355143-88-3	1999-09-10	LS20041355 (过期 overdue)
	硫氟肟醚 thiofluoximate^b	860028-12-2	2003-12-12	LS20140310 (过期 overdue)
	右旋反式氯丙炔菊酯	399572-87-3	1999-12-13	WP20170145
	呋喃虫酰肼 fufenozide^b	467427-81-1	2001-03-26	PD20121672
	丁虫腈 flufiprole^a	704886-18-0	2002-07-30	PD20120414
	氯噻啉 imidaclothiz^b	105843-36-5	2002-10-21	PD20082528
	哌虫啶 IPP-44	948994-16-9	2004-11-23	PD20171435
	氯氟醚菊酯 meperfluthrin^a	915288-13-0	2008-07-07	WP20110065
	四氯虫酰胺 tetrachlorantraniliprole^a	1104384-14-6	2008-07-07	PD20171752
	戊吡虫胍 guadipyr^b	1376342-13-0	2008-11-25	LS20170095 (过期 overdue)
	环氧虫啉	1185987-44-3	2008-12-17	LS20170342 (过期 overdue)
	环氧虫啶 cycloxaprid^b	1281863-13-5	2008-12-19	PD20184015
	氯溴虫腈 HNPC-A3061	890929-78-9	2009-06-29	LS20140332 (过期 overdue)
	乙唑螨腈 SYP-9625	1253429-01-4	2010-04-27	PD20181623
除草剂 Herbicides	单嘧磺隆 monosulfuron^b	155860-63-2	1994-12-07	PD20070369
	单嘧磺酯 monosulfuron-ester^b	175076-90-1	1994-12-07	PD20130372
	双甲胺草磷 H-9201	189517-75-7	1996-11-26	LS20051937 (过期 overdue)
	氯酰草膦 clacyfos^a	215655-76-8	1997-04-30	LS20071853 (过期 overdue)
	甲硫嘧磺隆 methiopyrsulfuron^b	441050-97-1	2000-05-11	LS20060244 (过期 overdue)
	丙酯草醚 pyribambenz-propyl^b	420138-40-5	2000-10-16	PD20141891
	异丙酯草醚 pyribambenz-isopropyl^b	420138-41-6	2000-10-16	PD20141888
	二氯喹啉草酮 G-18	1350901-36-8	2011-05-10	PD20184028
	环吡氟草酮	1855929-45-1	2015-11-06	PD20184021
	双唑草酮	1622908-18-2	2015-11-06	PD20184018
植物生长调节剂 Plant growth regulators	菊胺酯 WD-5	172351-12-1	1993-02-18	LS20030206 (过期 overdue)
	苯哒嗪丙酯 BAU9403	78778-15-1	1998-11-16	LS20020926 (过期 overdue)
	呋苯硫脲 fuphenthiourea^b	1332625-45-2	1999-12-15	LS20053285 (过期 overdue)
	14-羟基芸苔素甾醇 14-hydroxylated brassinosteroid^b	457603-63-3	2012-01-18	PD20171724
注：^a表示获得ISO通用名称；^b表示未获得ISO通用名称，是中国英文名称。Note: ^ais ISO common name. ^b is no ISO common name, the name is approved in China.

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