Abstract: With the development of unified prevention and control technology, the use of multiple pesticide formulations combined with spraying adjuvants has become one of the main application methods. However, it has also brought about the stability problem of tank mixing between formulation products or formulation/spray adjuvants of different enterprises. In this paper, three functional adjuvants including polyacrylic ester-based micro-crosslinking macromolecule polymer G-100A, fatty alcohol polyoxyethylene ether macromolecule polymer, andtristyrylphenol polyoxyethylene ether phosphate were used to prepare 40% difenoconazole + pyraclostrobin emulsion in water (EW). The field control efficacy on rice sheath blight was carried out. The results showed that the adhesion and deposition of the liquid of the as-prepared formulation on the target were significantly improved under the recommended concentration, and it also had good anti-evaporation performance. In terms of the prevention and control of rice sheath blight in the field, even if the dosage was reduced by 25%, the control efficiency was still the same as the control agent (40% difenoconazole +pyraclostrobin SC). In addition, G-100A can also be used as a spray adjuvant. It exists in the liquid with a unique structure, which can effectively inhibit water evaporation and droplets drift. Moreover, it can also reduce the interface energy when the droplet impacts the surface of target leaf, preventing the droplet bouncing. In summary, G-100A is expected to be applied in more formulation systems, which contributes to the reduction of pesticide application in the future.