Abstract:
To find nitrogen heterocyclic derivatives with higher antimicrobial activities, thirteen novel galactoside derivatives containing a pyrimidine moiety were synthesized, and their structures were confirmed by
1H NMR,
13C NMR and HRMS. The result of biological activity indicated that the target compounds possessed good antifungal activities against
Phytophthora infestans,
Gibberella zeae,
Thanatephorus cucumeris,
Botryosphaeria dothidea and
Phompsis sp
.. Among them, compound
4m showed excellent antifungal activities against
P. infestans , with the EC
50 value of 8.67 μg/mL, which were similar with that of dimethomorph (EC
50 value 8.34 μg/mL). Moreover, the target compounds exhibited certain antibacterial activities against
Xanthomonas citri subsp.
citri and
Xanthomonas oryzae pv.
oryzae.