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嘧菌酯/聚丙烯腈微球的制备及缓释性能

张钟凯 应彩娇 程志强 于晓斌

张钟凯, 应彩娇, 程志强, 于晓斌. 嘧菌酯/聚丙烯腈微球的制备及缓释性能[J]. 农药学学报, 2022, 24(3): 643-648. doi: 10.16801/j.issn.1008-7303.2022.0014
引用本文: 张钟凯, 应彩娇, 程志强, 于晓斌. 嘧菌酯/聚丙烯腈微球的制备及缓释性能[J]. 农药学学报, 2022, 24(3): 643-648. doi: 10.16801/j.issn.1008-7303.2022.0014
ZHANG Zhongkai, YING Caijiao, CHENG Zhiqiang, YU Xiaobin. Preparation and release properties of azoxystrobin/ polyacrylonitrile microspheres[J]. Chinese Journal of Pesticide Science, 2022, 24(3): 643-648. doi: 10.16801/j.issn.1008-7303.2022.0014
Citation: ZHANG Zhongkai, YING Caijiao, CHENG Zhiqiang, YU Xiaobin. Preparation and release properties of azoxystrobin/ polyacrylonitrile microspheres[J]. Chinese Journal of Pesticide Science, 2022, 24(3): 643-648. doi: 10.16801/j.issn.1008-7303.2022.0014

嘧菌酯/聚丙烯腈微球的制备及缓释性能

doi: 10.16801/j.issn.1008-7303.2022.0014
基金项目: 吉林省科技厅计划项目(20210509025RQ);吉林省发展改革委员会能力建设项目(2019C050-9).
详细信息
    作者简介:

    张钟凯,546895471@qq.com

    应彩娇,1315340296@qq.com

    通讯作者:

    于晓斌,446745723@qq.com

  • 中图分类号: S481.9;TQ450.6

Preparation and release properties of azoxystrobin/ polyacrylonitrile microspheres

Funds: the Jilin Province Science and Technology Development Project (20210509025RQ), Jilin Province Innovation Capacity Building Fund Project (2019C050-9).
  • 摘要: 采用聚丙烯腈(PAN)为原料,通过静电喷雾技术制备了载有嘧菌酯的PAN微球。研究了工作电压、嘧菌酯与PAN质量比对微球形貌与性能的影响,并通过释放试验评价了载药微球的缓释性能。结果表明:静电纺丝机的工作电压是控制微球粒径大小的主要因素,其粒径随电压增大而减小,最小可至0.86 μm,而嘧菌酯与PAN的质量比则主要影响微球的载药量与包封率,微球载药量最高可达34.53%,包封率最高可达79.78%。此外,载药微球在3种不同pH的缓冲溶液中均实现了长达400 min的稳定释放,表明其具有出色的缓释性能。在静电纺丝机工作电压15 kV、工作距离20 cm、PAN溶液质量浓度2%、m(嘧菌酯) : m(PAN) = 1 : 2 及进样速率1.25 mL/h的条件下,可制备具有良好形貌与缓释性能的嘧菌酯/PAN微球,本研究可为农药减量增效提供一种技术路径。
  • 图  1  静电喷雾实验装置图

    Figure  1.  Diagram of electrostatic spray experimental device

    图  2  工作电压分别在13、14 和15 kV下载药微球SEM图(A~C)和粒径分布(a~c)

    Figure  2.  The SEM images(A-C) and particle size distribution(a-c) of the microspheres recorded under the working voltages of 13, 14 and 15 kV

    图  3  不同pH缓冲溶液中的累积释药曲线

    (a)载药微球中的嘧菌酯; (b)嘧菌酯原药。

    Figure  3.  Cumulative release curve in buffer solutions with different pH

       (a) azoxystrobin in polyacrylonitrile microspheres;           (b) azoxystrobin.

    表  1  不同pH值磷酸盐缓冲溶液的配制

    Table  1.   Preparation of phosphate buffer solutions with different pH

    pH体积分数 Volume ratio, V/%
    0.2 mol/L KH2PO4
    0.2 mol/L K2HPO4
    0.1 mol/L TC
    5 51.00 49.00
    7 40.00 60.00
    8 5.50 94.50
    下载: 导出CSV

    表  2  嘧菌酯与PAN质量比对载药微球的影响

    Table  2.   Influence of the mass ratio of azoxystrobin and polyacrylonitrile on drug-loaded microspheres

    m (嘧菌酯) : m (PAN)m (azoxystrobin) : m (PAN)直径Diameter/
    µm
    载药量Loading
    capacity/%
    包封率Encapsulation
    efficiency/%
    1 : 2 0.89 ± 0.09 26.59 ± 0.36 79.78
    1 : 1 0.87 ± 0.07 30.55 ± 1.34 61.10
    2 : 1 0.86 ± 0.08 34.53 ± 1.31 51.79
    下载: 导出CSV

    表  3  不同剂型嘧菌酯对黄瓜炭疽病的防治效果

    Table  3.   Control efficacy of azoxystrobin with different formulations on cucumber anthracnose

    处理
    Treatment
    有效成分质量浓度Concentration,
    a.i/(g/L)
    防治效果
    Control efficacy/%
    处理后7 d7 d after
    spray
    处理后14 d14 d after
    spray
    清水
    CK (Water)
    25%嘧菌酯悬浮剂
    azoxystrobin 25% SC
    0.2 79.58 Bb 54.46 Bb
    嘧菌酯/PAN微球悬浮剂
    azoxystrobin/PAN microspheres SC
    0.2 51.19 Aa 26.36 Aa
    0.3 71.12 Bb 55.41 Bb
    0.4 73.48 Bb 61.08 Bb
    注:表中数据后的大小写字母分别表示在5%、1%水平下的显著性差异。Note: The upper and lower case letters after the data in the table indicate significant differences at the 5% and 1% levels, respectively.
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-05-19
  • 录用日期:  2021-12-21
  • 网络出版日期:  2022-02-18
  • 刊出日期:  2022-06-10

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