Abstract: In this study, tebuconazole@hollow mesoporous nano silica (Teb@HMS) sustained release granules were prepared. The morphology, structure, and properties were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), specific surface area analyzer (BET), thermogravimetric analyzer (TGA), and other instruments. The release behavior of tebuconazole in sustained-release granules was investigated by high-performance liquid chromatography (HPLC) analysis. The inhibitory activity of Teb@HMS on Rhizoctonia solani was determined by mycelial growth inhibition, potted experiments, and field control efficacy experiments . The safety of Teb@HMS was evaluated through rice seed germination experiments and zebrafish experiments. It was shown that the prepared drug-loaded nanosilica particles exhibited a regular hollow mesoporous structure. The drug loading rate for tebuconazole was 52.02% and the sustained release time was up to 400 hours. Meanwhile, Teb@HMS reduced the toxicity of tebuconazole to non-target rice seeds and zebrafish. The antifungal activity of Teb@HMS was significantly better than the positive control tebuconazole. On the 18th day of pot and field trails, Teb@HMS protection efficacy reached 61.79% and 70.42%, respectively. This study provides technical support and theoretical guidance for the application of hollow mesoporous nano silica sustained-release granules in pesticide reduction and green and sustainable prevention and control of plant diseases.