Abstract: Many researches demonstrate that the first‘green revolution’and the encoding gene of plant hormone are inseparable from each other. Plant growth is regulated by phytohormone and phytohormone receptor is the key player in this process. Hence, phytohormone receptor has been increasingly a major concern in this field. Recently, great progress has been found in the crystal structure study of phytohormone receptor, which induced a more deeply understanding of the molecular mechanism. The recent progress of crystal structures and molecular mechanism of auxin, gibberellin, and abscisic acid were summarized to make a contribution for the structure-based bio-rational design of novel synthetic phytohormone.