含取代2-苯基吡啶基团的甲氧基氨基甲酸酯类化合物的合成及杀螨活性

Synthesis and acaricidal activity of methoxylcarbamates containing substituted 2-phenylpyridine moieties

摘要: 以取代2-溴吡啶和羟基苯硼酸为原料，经Suzuki偶联和亲核取代两步反应合成了9个未见报道的含取代2-苯基吡啶基团的甲氧基氨基甲酸酯类化合物，其结构均经红外光谱、核磁共振氢谱及质谱（ESI-MS）表征。初步生物活性测定结果表明：在500 mg/L下，部分化合物对朱砂叶螨Tetranychus cinnabarinus的致死率达100%，具有作为杀螨剂先导结构的潜力。

Abstract: Nine novel methoxylcarbamates containing substituted 2-phenylpyridine moieties were synthesized from hydroxyphenylboronic acid and substituted 2-bromopyridine via Suzuki cross-coupling reaction and nucleophilic substitution sequence. Their structures were characterized by IR,1H NMR and ESI-MS. The preliminary bioassay showed that some compounds exhibited excellent lethality against Tetranychus cinnabarinus at 500 mg/L. The results indicated that above methoxylcarbamates can serve as potential acaricidal lead compounds.