(E)-O-芳酰基-α-氧代环十二酮肟的合成及除草活性

SYNTHESIS AND HERBICIDAL ACTIVITIES OF (E) O AROYL α OXOCYCLODODECANONE OXIMES

摘要: 以环十二酮为原料 ,制得中间体 (E) -α-氧代环十二酮肟 (Ⅳ)后 ,经酰化合成了九个 (E) - O-芳酰基 -α-氧代环十二酮肟 (Ⅴ) ,它们的结构得到元素分析、IR和 1HNMR的确证。生测结果表明 ,部分化合物具有良好的除草活性。对活性较高的 3还通过精密毒力测定 ,求得 IC50 值。中间体在贝克曼反应条件下发生断裂反应生成 11-氰基十一酸 (Ⅶ) ,证实了具有 (E) -构型的结构特征。

Abstract: Nine (E) O aroyl α oxocyclododecanone oxime(V1 V9) were synthesized from cyclododecanone: ZJLX,YS;X O CH 3ONO0-5℃ ZJLX,YS;X O ZJLX,YX;Z N OH IV ArCOOH,DCC/CH 2Cl 2R.T. ZJLX,YS;X O ZJLX,YX;Z N OCO Ar V Their structures were confirmed by IR, 1HNMR and elemental analysis. The bioassay of all the title compounds was carried out. The results showed that some of them possess herbicidal activities, among them V3 has good herbicidal activities. (E) configuration of α oxocyclododecanone oxime was confirmed by its Beckmann reaction which gives 11 cyanoundodecanoic acid.