6-甲基-4-羟基-2-吡喃酮及其3-羧酸衍生物的简便合成方法
SIMPLE AND CONVENIENT SYNTHESES OF 4HYDROXY6METHYL2PYRONE AND ITS 3CARBOXY DERIVATIVE
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Abstract: In this paper, it was found that isopropylidene (1-hydroxy-3-oxo-butylidene) malonate 4 was a heat unstable compound and the one step convenient methods for preparation of 4-hydroxy-6-methyl-2-pyrone 1 and 3-carboxy-4-hydroxy-6-methyl-2-pyrone 2 in good yields were reported. Isopropylidene malonate 3、diketen and triethylamine reacted in chloroform to give 2, and in the mixture of dichloromethane and chlorobenzene to offer 1.