芳基芳酰基取代氨基脲类昆虫生长调节剂的合成及构效关系研究
STUDY ON SYNTHESIS AND QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF 1-AROYL-4-ARYL-2-t-BUTYL SEMICARBAZIDES
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摘要: 将昆虫生长调节剂灭幼脲的活性基团和蜕皮激素模拟物 RH- 584 9和 RH- 5992的活性基团进行拼接 ,合成了十二个全新的 2 -叔丁基 - 1-芳酰基 - 4 -芳基氨基脲类目标化合物 ,其结构经 IR,1H NMR,MS和元素分析确证。生物测试结果表明 ,该系列化合物有一定的昆虫生长调节活性。通过 QSAR分析 ,找出了该系列化合物的结构 -活性定量方程 ,并进行了统计学和化学的检验。也为今后继续优化该系列化合物提供理论依据。Abstract: On the basis of benzoylphenylurea larvicides and the molting hormones and their mimics, a series of 1-aroyl-4-aryl-2-t-butyl semicarbazides were synthesized. Their structures were characterized by IR, 1H NMR-,MS and elemental analysis. The bioassay showed some target compounds had good insect growth regulating- activity. The quantitative structure-activity relationship have been established.